Wnt1

WNT1
Identifiants
Alias	WNT1
IDs externes	OMIM: 164820 MGI: 98953 HomoloGene: 3963 GeneCards: WNT1
Position du gène (humain) Chr. Chromosome 12 humain Locus 12q13.12 Début 48,978,322 bp Fin 48,982,620 bp
Position du gène (souris) Chr. Chromosome 15 (souris) Locus 15 F1|15 54.65 cM Début 98,687,738 bp Fin 98,691,718 bp
Expression génique Bgee Humain Souris (orthologue) Fortement exprimé dans granulocyte noyau accumbens gyrus frontal supérieur right frontal lobe cortex préfrontal putamen sang noyau caudé moelle osseuse Brodmann area 9 Fortement exprimé dans muscle layer of urethra pelvic part of vagina rhombic lip canal éjaculateur perineal part of vagina masse cellulaire interne epithelium of seminiferous tubule of testis choroid plexus of fourth ventricle female urethra morula Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire cytokine activity protein domain specific binding frizzled binding morphogen activity signaling receptor binding receptor ligand activity Composant cellulaire cytoplasme endocytic vesicle membrane endoplasmic reticulum lumen membrane plasmique région extracellulaire surface cellulaire Golgi lumen exosome milieu extracellulaire Processus biologique negative regulation of cell-substrate adhesion forebrain anterior/posterior pattern specification dopaminergic neuron differentiation neurogenèse cell fate commitment negative regulation of fat cell differentiation positive regulation of protein phosphorylation myotube differentiation metencephalon development midbrain-hindbrain boundary maturation during brain development T cell differentiation in thymus spinal cord association neuron differentiation negative regulation of cell-cell adhesion neuron fate determination signal transduction in response to DNA damage central nervous system morphogenesis positive regulation of fibroblast proliferation positive regulation of dermatome development cell-cell signaling negative regulation of cell differentiation hematopoietic stem cell proliferation cell proliferation in midbrain positive regulation of DNA-binding transcription factor activity embryonic axis specification hepatocyte differentiation negative regulation of transforming growth factor beta receptor signaling pathway cerebellum development ubiquitin-dependent SMAD protein catabolic process cerebellum formation negative regulation of BMP signaling pathway canonical Wnt signaling pathway involved in negative regulation of apoptotic process régulation positive de la transcription dépendante de l'ADN développent d'un organisme multicellulaire diencephalon development branching involved in ureteric bud morphogenesis cellular response to peptide hormone stimulus midbrain-hindbrain boundary development embryonic brain development response to wounding positive regulation of insulin-like growth factor receptor signaling pathway inner ear morphogenesis animal organ regeneration positive regulation of cell population proliferation negative regulation of ubiquitin-dependent protein catabolic process neuron fate commitment myoblast fusion positive regulation of lamellipodium assembly développement osseux Spemann organizer formation midbrain development positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II Voie de signalisation Wnt astrocyte-dopaminergic neuron signaling positive regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Wnt signaling pathway, planar cell polarity pathway beta-catenin destruction complex disassembly negative regulation of oxidative stress-induced neuron death regulation of signaling receptor activity canonical Wnt signaling pathway negative regulation of apoptotic process différenciation d'un neurone Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 7471 22408 Ensembl ENSG00000125084 ENSMUSG00000022997 UniProt P04628 P04426 RefSeq (mRNA) NM_005430 NM_021279 RefSeq (protéine) NP_005421 NP_067254 Localisation (UCSC) Chr 12: 48.98 – 48.98 Mb Chr 15: 98.69 – 98.69 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

Wnt1 est une protéine de la famille Wnt codée par le gène Wnt1.

Structure

Il s'agit d'une glycoprotéine dont le gène se situe sur le chromosome 12 humain.

Rôles

Elle intervient dans le développement du cerveau du fœtus et a un rôle dans le développement de certains cancers chez la souris par sa forme soluble.

En médecine

Une mutation du gène peut entrainer une forme récessive d'ostéogenèse imparfaite ou une ostéoporose familiale précoce.